Xueying Chen Selected Research

JDQ443

1/2022

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.

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Xueying Chen Research Topics

Disease

12	Neoplasms (Cancer) 01/2023 - 04/2013
11	Heart Failure 11/2023 - 10/2017
5	Fibrosis (Cirrhosis) 12/2022 - 10/2014
4	Infections 10/2023 - 01/2019
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2024 - 01/2017
3	Bundle-Branch Block (Fascicular Block) 11/2022 - 01/2020
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2022 - 01/2016
3	Inflammation (Inflammations) 11/2020 - 06/2013
3	Atherosclerosis 10/2019 - 04/2011
2	Cardiovascular Diseases (Cardiovascular Disease) 04/2024 - 01/2019
2	Hypoxia (Hypoxemia) 12/2023 - 02/2014
2	Pathologic Constriction (Stenosis) 07/2023 - 01/2016
2	Hemorrhage 04/2023 - 01/2023
2	Breast Neoplasms (Breast Cancer) 01/2023 - 12/2019
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2023 - 11/2020
2	Atrial Fibrillation 12/2022 - 01/2022
2	Pericardial Effusion 01/2021 - 01/2015
2	Bovine Mastitis 03/2020 - 01/2018
2	Cardiomyopathies (Cardiomyopathy) 01/2020 - 10/2017
2	Myocardial Infarction 05/2018 - 02/2014
2	Hyperphosphatemia 01/2018 - 01/2017
2	Diabetes Mellitus 09/2016 - 12/2015
2	Left Ventricular Dysfunction 09/2016 - 04/2011
2	Coronary Disease (Coronary Heart Disease) 04/2011 - 11/2009
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 12/2023
1	Metabolic Diseases (Metabolic Disease) 11/2023
1	Pathologic Processes 11/2023
1	Peritonitis 10/2023
1	Brain Diseases (Brain Disorder) 07/2023
1	Hypersensitivity (Allergy) 07/2023
1	Bradycardia 06/2023
1	Thrombosis (Thrombus) 04/2023
1	Arterial Occlusive Diseases (Arterial Occlusive Disease) 04/2023
1	Nausea 03/2023
1	Tumor Lysis Syndrome 03/2023
1	Cardiotoxicity 01/2023
1	Triple Negative Breast Neoplasms 01/2023
1	Hematoma 01/2023
1	Neoplasm Metastasis (Metastasis) 01/2023
1	Liver Cirrhosis (Hepatic Cirrhosis) 12/2022
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 12/2022
1	Organizing Pneumonia 01/2022

Drug/Important Bio-Agent (IBA)

4	CollagenIBA 01/2022 - 12/2015
4	Lipoproteins (Lipoprotein)IBA 01/2016 - 11/2009
3	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 09/2016
3	infigratinibIBA 12/2019 - 01/2017
2	Proteins (Proteins, Gene)FDA Link 11/2023 - 01/2019
2	Anti-Bacterial Agents (Antibiotics)IBA 10/2023 - 01/2022
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2023 - 11/2020
2	Biomarkers (Surrogate Marker)IBA 12/2022 - 01/2020
2	neferineIBA 01/2022 - 09/2016
2	Therapeutic UsesIBA 11/2020 - 02/2014
2	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 12/2019 - 01/2017
2	Estrogen ReceptorsIBA 12/2019 - 10/2019
2	Cholesterol Ester Transfer ProteinsIBA 01/2019 - 01/2016
2	mitochondrial calcium uniporterIBA 01/2019 - 11/2018
2	Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA 01/2018 - 01/2017
1	pembrolizumabIBA 01/2024
1	zimberelimabIBA 01/2024
1	Immunoglobulins (Immunoglobulin)IBA 01/2024
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2023
1	Estrogen Receptor alphaIBA 12/2023
1	Interleukin-6 (Interleukin 6)IBA 12/2023
1	Cysteine (L-Cysteine)FDA Link 11/2023
1	Dextrans (Dextran)FDA Link 10/2023
1	Contrast MediaIBA 07/2023
1	Sulfadiazine (Sulphadiazine)FDA Link 05/2023
1	SodiumIBA 05/2023
1	Gallic AcidIBA 05/2023
1	Rutin (Rutoside)IBA 04/2023
1	BilirubinIBA 03/2023
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 03/2023
1	Alanine Transaminase (SGPT)IBA 03/2023
1	SuspensionsIBA 01/2023
1	Immune Checkpoint InhibitorsIBA 01/2023
1	AnthracyclinesIBA 01/2023
1	p38 Mitogen-Activated Protein KinasesIBA 12/2022
1	ImmunosorbentsIBA 12/2022
1	EnzymesIBA 12/2022
1	MEF2 Transcription FactorsIBA 12/2022
1	ribociclibIBA 01/2022
1	JDQ443IBA 01/2022
1	ceritinibIBA 01/2022
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022
1	Apolipoproteins E (ApoE)IBA 01/2022

Therapy/Procedure

9	Cardiac Resynchronization Therapy 06/2023 - 10/2017
5	Therapeutics 07/2023 - 01/2020
3	Drug Therapy (Chemotherapy) 01/2024 - 09/2015
3	Radiotherapy 11/2018 - 10/2014
2	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 12/2023 - 11/2018
2	Patient Readmission 11/2023 - 01/2023
2	Immunotherapy 01/2023 - 02/2019
2	Percutaneous Coronary Intervention 01/2022 - 05/2018
1	Exercise Therapy (Therapy, Exercise) 04/2024
1	Secondary Prevention 04/2024
1	Heart Transplantation (Grafting, Heart) 11/2023
1	Punctures 01/2023
1	Photothermal Therapy 01/2023
1	Cannula 01/2023
1	Fecal Microbiota Transplantation 01/2022